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ea0044p191 | Obesity and Metabolism | SFEBES2016

Freeze dried broccoli extract relieves ER stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells

Murphy Alice , de la Escalera Clapp Lucia Martinez , Jackisch Laura , Azharian Sahar , Aladel Alanoud , Barker Guy , Tripathi Gyanendra , Chappell Michael , McTernan Philip

Background: In obesity, excess nutrients can disrupt protein folding in the endoplasmic reticulum (ER) which activates the unfolded protein response (UPR) and alters mitochondrial function. These changes can induce inflammation, oxidative stress and insulin resistance. The aim of the study was to investigate whether broccoli extract can protect against cellular damage in human adipocytes, which with mathematical modelling may help predict pathway response.<p class="abstext...

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ea0038fp7 | (1) | SFEBES2015

Regulation of adipogenesis by wnt10b signalling in cultured human adipocytes taken from an obese patient with a WNT10B-C256Y mutation

Azharian Sahar , Voyias Philip D , Murphy Alice , de la Escalera Clapp Lucia Martinez , Adaikalakoteswari Antonysunil , Saravanan Ponnusamy , Piya Milan K , McTernan Philip G , Tripathi Gyanendra

Background: Adipogenesis is a key process leading to adipose tissue (AT) expansion. However, managing this event is critical to limit excessive fat accumulation and disease risk. Adipogenesis appears controlled in part, through Wnt10b signalling which reduces adipogenesis via inhibiting CCAAT/enhancer-binding protein alpha (CEBPα) although the molecular mechanism remains unclear.Aims: Abdominal subcutaneous AT (AbdSc AT) was collected from a, non-di...

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Endocrine Abstracts

Freeze dried broccoli extract relieves ER stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells

Regulation of adipogenesis by wnt10b signalling in cultured human adipocytes taken from an obese patient with a WNT10B-C256Y mutation

BiosciAbstracts